A screen of small molecule and genetic modulators of life span in female Drosophila identifies etomoxir, RH5849 and unanticipated temperature effects

Mifepristone increases life span in female Drosophila melanogaster, and its molecular target(s) remain unclear. Here small molecule and genetic interventions were tested for ability to mimic mifepristone, or to decrease life span in a way that can be rescued by mifepristone. Etomoxir inhibits lipid...

Full description

Bibliographic Details
Main Authors: Gary N. Landis, Sebastian Ko, Oscar Peng, Brett Bognar, Michael Khmelkov, Hans S. Bell, John Tower
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Fly
Subjects:
Online Access:http://dx.doi.org/10.1080/19336934.2022.2149209