The Virulence of Escherichia coli O157:H7 Isolates in Mice Depends on Shiga Toxin Type 2a (Stx2a)-Induction and High Levels of Stx2a in Stool

The Virulence of Escherichia coli O157:H7 Isolates in Mice Depends on Shiga Toxin Type 2a (Stx2a)-Induction and High Levels of Stx2a in Stool

In this study we compared nine Shiga toxin (Stx)-producing Escherichia coli O157:H7 patient isolates for Stx levels, stx-phage insertion site(s), and pathogenicity in a streptomycin (Str)-treated mouse model. The strains encoded stx2a, stx1a and stx2a, or stx2a and stx2c. All of the strains elaborat...

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Bibliographic Details
Main Authors: Jocelyn R. Hauser, Rama R. Atitkar, Courtney D. Petro, Rebecca L. Lindsey, Nancy Strockbine, Alison D. O'Brien, Angela R. Melton-Celsa
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Escherichia coli
O157:H7
Shiga toxin
Stx2
phage
recA
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00062/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2020.00062/full

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