Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant

Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant

Microbes frequently evolve in reproducible ways. Here, we show that differences in specific metabolic regulation rather than inter-strain interactions explain the frequent presence of lasR loss-of-function (LOF) mutations in the bacterial pathogen Pseudomonas aeruginosa. While LasR contributes to vi...

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Bibliographic Details
Main Authors: Dallas L Mould, Mirjana Stevanovic, Alix Ashare, Daniel Schultz, Deborah A Hogan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
Pseudomonas aeruginosa
quorum sensing
LasR
evolution
carbon catabolite repression
Online Access:https://elifesciences.org/articles/76555

Internet

https://elifesciences.org/articles/76555

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