Sequence-based identification of amyloidogenic β-hairpins reveals a prostatic acid phosphatase fragment promoting semen amyloid formation

Sequence-based identification of amyloidogenic β-hairpins reveals a prostatic acid phosphatase fragment promoting semen amyloid formation

β-Structure-rich amyloid fibrils are hallmarks of several diseases, including Alzheimer’s (AD), Parkinson’s (PD), and type 2 diabetes (T2D). While amyloid fibrils typically consist of parallel β-sheets, the anti-parallel β-hairpin is a structural motif accessible to amyloidogenic proteins in their m...

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Bibliographic Details
Main Authors: Laetitia F. Heid, Emil Dandanell Agerschou, Asuka A. Orr, Tatsiana Kupreichyk, Walfried Schneider, Michael M. Wördehoff, Melanie Schwarten, Dieter Willbold, Phanourios Tamamis, Matthias Stoldt, Wolfgang Hoyer
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Amyloid
β-hairpin
Protein misfolding
Protein aggregation
Proteopathy
Semen amyloid
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023004993

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http://www.sciencedirect.com/science/article/pii/S2001037023004993

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