Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation

Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation

Influenza virus infections represent a major public health issue by causing annual epidemics and occasional pandemics that affect thousands of people worldwide. Vaccination is the main prophylaxis to prevent these epidemics/pandemics, although the effectiveness of licensed vaccines is rather limited...

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Bibliographic Details
Main Authors: Laurita Boff, André Schreiber, Aline da Rocha Matos, Juliana Del Sarto, Linda Brunotte, Jennifer Munkert, Flaviano Melo Ottoni, Gabriela Silva Ramos, Wolfgang Kreis, Fernão Castro Braga, Ricardo José Alves, Rodrigo Maia de Pádua, Cláudia Maria Oliveira Simões, Stephan Ludwig
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
semisynthetic cardenolides
anti-influenza
mechanism of action
polymerase activity inhibition
Online Access:https://www.mdpi.com/1420-3049/25/20/4853

Internet

https://www.mdpi.com/1420-3049/25/20/4853

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