SUITOR: Selecting the number of mutational signatures through cross-validation.

For de novo mutational signature analysis, the critical first step is to decide how many signatures should be expected in a cancer genomics study. An incorrect number could mislead downstream analyses. Here we present SUITOR (Selecting the nUmber of mutatIonal signaTures thrOugh cRoss-validation), a...

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Bibliographic Details
Main Authors: Donghyuk Lee, Difei Wang, Xiaohong R Yang, Jianxin Shi, Maria Teresa Landi, Bin Zhu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-04-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1009309