Coenzyme Q0, a quinone derivative from Antrodia camphorata, inhibits epithelial-mesenchymal transition by activating the Nrf2 signaling pathway in TGF-β-stimulated adult retinal pigment epithelial cells to improve age-related macular degeneration and proliferative vitreoretinopathy

Coenzyme Q0, a quinone derivative from Antrodia camphorata, inhibits epithelial-mesenchymal transition by activating the Nrf2 signaling pathway in TGF-β-stimulated adult retinal pigment epithelial cells to improve age-related macular degeneration and proliferative vitreoretinopathy

We investigated the anti-EMT and antifibrotic effects of coenzyme Q0 (CoQ0), a quinone derivative from Antrodia camphorata, in TGF-β-stimulated adult retinal pigment epithelial 19 (ARPE-19) cells. Results showed that CoQ0 treatment reversed TGF-β-stimulated morphological changes from an epithelial t...

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Bibliographic Details
Main Authors: Hsin-Ling Yang, Hung-Rong Yen, I-Chen Chang, Chithravel Vadivalagan, Siang-Jyun Chen, Chuan-Chen Lee, Wei-Chen Jane, Jhih-Hsuan Hseu, You-Cheng Hseu
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Journal of Functional Foods
Subjects:
Coenzyme Q0
ARPE-19
TGF-β
ROS
EMT
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464623005789

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http://www.sciencedirect.com/science/article/pii/S1756464623005789

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