TurboID screening of ApxI toxin interactants identifies host proteins involved in Actinobacillus pleuropneumoniae-induced apoptosis of immortalized porcine alveolar macrophages

TurboID screening of ApxI toxin interactants identifies host proteins involved in Actinobacillus pleuropneumoniae-induced apoptosis of immortalized porcine alveolar macrophages

Abstract Actinobacillus pleuropneumoniae (APP) is a gram-negative pathogenic bacterium responsible for porcine contagious pleuropneumonia (PCP), which can cause porcine necrotizing and hemorrhagic pleuropneumonia. Actinobacillus pleuropneumoniae-RTX-toxin (Apx) is an APP virulence factor. APP secret...

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Bibliographic Details
Main Authors: Yaofang Hu, Changsheng Jiang, Yueqiao Zhao, Hua Cao, Jingping Ren, Wei Zeng, Mengjia Zhang, Yongtao Li, Qigai He, Wentao Li
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Veterinary Research
Subjects:
Actinobacillus pleuropneumoniae
ApxI exotoxin
TurboID enzyme-catalyzed proximity labeling method
interacting proteomes
Online Access:https://doi.org/10.1186/s13567-023-01194-6

Internet

https://doi.org/10.1186/s13567-023-01194-6

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