Functional Characterization of 15 Novel Dense Granule Proteins in Toxoplasma gondii Using the CRISPR-Cas9 System

Functional Characterization of 15 Novel Dense Granule Proteins in Toxoplasma gondii Using the CRISPR-Cas9 System

ABSTRACT The analysis of the subcellular localization and function of dense granule proteins (GRAs) is of central importance for the understanding of host-parasite interaction and pathogenesis of Toxoplasma gondii infection. Here, we identified 15 novel GRAs and used C-terminal endogenous gene taggi...

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Bibliographic Details
Main Authors: Xiao-Nan Zheng, Jin-Lei Wang, Hany M. Elsheikha, Meng Wang, Zhi-Wei Zhang, Li-Xiu Sun, Xin-Cheng Wang, Xing-Quan Zhu, Ting-Ting Li
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
Toxoplasma gondii
dense granule proteins
subcellular localization
virulence
cysts
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03078-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.03078-22

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