Characterization and modulation of anti-αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells

Characterization and modulation of anti-αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells

T cell engineering strategies offer cures to patients and have entered clinical practice with chimeric antibody-based receptors; αβT cell receptor (αβTCR)-based strategies are, however, lagging behind. To allow a more rapid and successful translation to successful concepts also using αβTCRs for engi...

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Bibliographic Details
Main Authors: Guido J.J. Kierkels, Eline van Diest, Patricia Hernández-López, Wouter Scheper, Anja C.M. de Bruin, Elselien Frijlink, Tineke Aarts-Riemens, Sanne F.J. van Dooremalen, Dennis X. Beringer, Rimke Oostvogels, Lovro Kramer, Trudy Straetemans, Wolfgang Uckert, Zsolt Sebestyén, Jürgen Kuball
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
immunotherapy
T cell engineering
select-kill strategy
epitope mapping
T cell depletion
T cell repector (TCR)
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121001133

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http://www.sciencedirect.com/science/article/pii/S2329050121001133

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