RAGE–TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages

RAGE–TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages

The receptor of advanced glycation end products (RAGE) and Toll-like receptor 4 (TLR4) are important receptors for inflammatory responses induced by high glucose (HG) and lipopolysaccharide (LPS) and show crosstalk phenomena in inflammatory responses. However, it is unknown whether RAGE and TLR4 can...

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Bibliographic Details
Main Authors: Longfei Yan, Yanran Li, Tianyu Tan, Jiancheng Qi, Jing Fang, Hongrui Guo, Zhihua Ren, Liping Gou, Yi Geng, Hengmin Cui, Liuhong Shen, Shumin Yu, Zhisheng Wang, Zhicai Zuo
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
TLR4–RAGE crosstalk
glucose
lipopolysaccharide (LPS)
inflammatory
alveolar macrophages
Online Access:https://www.mdpi.com/1422-0067/24/8/7007

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https://www.mdpi.com/1422-0067/24/8/7007

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