Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis

Abstract Background Pneumococcal meningitis is associated with high risk of neurological sequelae such as cognitive impairment and hearing loss. These sequelae are due to parenchymal brain and inner ear damage primarily induced by the excessive inflammatory reaction in response to bacterial brain in...

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Bibliographic Details
Main Authors: Lukas Muri, Ngoc Dung Le, Jonas Zemp, Denis Grandgirard, Stephen L. Leib
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Neuroinflammation
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12974-019-1549-6