Construction and validation of a novel lysosomal signature for hepatocellular carcinoma prognosis, diagnosis, and therapeutic decision-making

Abstract Lysosomes is a well-recognized oncogenic driver and chemoresistance across variable cancer types, and has been associated with tumor invasiveness, metastasis, and poor prognosis. However, the significance of lysosomes in hepatocellular carcinoma (HCC) is not well understood. Lysosomes-relat...

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Bibliographic Details
Main Authors: Jianlin Chen, Gan Gao, Yufang He, Yi Zhang, Haixia Wu, Peng Dai, Qingzhu Zheng, Hengbin Huang, Jiamiao Weng, Yue Zheng, Yi Huang
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-49985-3