The α-Tomatine Exhibits Antiproliferative Activity, Rupture of Cell Membranes and Induces the Expression of APC Gene in the Human Colorectal Adenocarcinoma Cell Line (Ht-29)

The α-Tomatine Exhibits Antiproliferative Activity, Rupture of Cell Membranes and Induces the Expression of APC Gene in the Human Colorectal Adenocarcinoma Cell Line (Ht-29)

Abstract The α-tomatine is a steroidal glycoalkaloid found in immature tomatoes (Lycopersicon esculentum) that has important biological functions including the inhibition of cancer cell growth and preventing metastasis. This study aimed to evaluate the effects of α-tomatine on cytotoxicity, cellular...

Full description

Bibliographic Details
Main Authors: Priscila Lumi Ishii, Rodrigo Juliano Oliveira, Mariana de Oliveira Mauro, Verônica Assalin Zorgetto-Pinheiro, Daniele Sartori, Sandra Regina Lepri, Adrivanio Baranoski, Mário Sérgio Mantovani, Lúcia Regina Ribeiro
Format: Article
Language:English
Published: Instituto de Tecnologia do Paraná (Tecpar) 2020-10-01
Series:Brazilian Archives of Biology and Technology
Subjects:
alpha-tomatine
gene expression
cytotoxicity
cell cycle
DNA damage
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132020000100331&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132020000100331&tlng=en

Similar Items