Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice

Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice

Alzheimer’s disease: A tool for preventing toxic tangles The discovery that an already approved drug can disrupt tau protein aggregation in cultured cells and live mice could guide the development of new therapies for Alzheimer’s. Tau plays an important role in organizing the internal structure of n...

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Bibliographic Details
Main Authors: Sungsu Lim, Seulgi Shin, Yoonsik Sung, Ha Eun Lee, Kyu Hyeon Kim, Ji Yeon Song, Gwan-Ho Lee, Hira Aziz, Nataliia Lukianenko, Dong Min Kang, Nicolette Boesen, Hyeanjeong Jeong, Aizhan Abdildinova, Junghee Lee, Byung-Yong Yu, Sang Min Lim, Jun-Seok Lee, Hoon Ryu, Ae Nim Pae, Yun Kyung Kim
Format: Article
Language:English
Published: Nature Publishing Group 2023-03-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-023-00959-5

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https://doi.org/10.1038/s12276-023-00959-5

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