NK cells contribute to reovirus-induced IFN responses and loss of tolerance to dietary antigen

NK cells contribute to reovirus-induced IFN responses and loss of tolerance to dietary antigen

Celiac disease is an immune-mediated intestinal disorder that results from loss of oral tolerance (LOT) to dietary gluten. Reovirus elicits inflammatory Th1 cells and suppresses Treg responses to dietary antigen in a strain-dependent manner. Strain type 1 Lang (T1L) breaks oral tolerance, while stra...

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Bibliographic Details
Main Authors: Pamela H. Brigleb, Elaine Kouame, Kay L. Fiske, Gwen M. Taylor, Kelly Urbanek, Luzmariel Medina Sanchez, Reinhard Hinterleitner, Bana Jabri, Terence S. Dermody
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-08-01
Series:JCI Insight
Subjects:
Immunology
Virology
Online Access:https://doi.org/10.1172/jci.insight.159823

Internet

https://doi.org/10.1172/jci.insight.159823

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