Altered TGFβ/SMAD Signaling in Human and Rat Models of Pulmonary Hypertension: An Old Target Needs Attention

Altered TGFβ/SMAD Signaling in Human and Rat Models of Pulmonary Hypertension: An Old Target Needs Attention

Recent translational studies highlighted the inhibition of transforming growth factor (TGF)-β signaling as a promising target to treat pulmonary arterial hypertension (PAH). However, it remains unclear whether alterations in TGF-β signaling are consistent between PAH patients and animal models. Ther...

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Bibliographic Details
Main Authors: Takayuki Jujo Sanada, Xiao-Qing Sun, Chris Happé, Christophe Guignabert, Ly Tu, Ingrid Schalij, Harm-Jan Bogaard, Marie-José Goumans, Kondababu Kurakula
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
pulmonary arterial hypertension
TGF-β signaling
SMADs
animal models of pulmonary hypertension
Online Access:https://www.mdpi.com/2073-4409/10/1/84

Internet

https://www.mdpi.com/2073-4409/10/1/84

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