The effect of disease misclassification on the ability to detect a gene-environment interaction: implications of the specificity of case definitions for research on Gulf War illness

The effect of disease misclassification on the ability to detect a gene-environment interaction: implications of the specificity of case definitions for research on Gulf War illness

Abstract Background Since 1997, research on Gulf War illness (GWI) has predominantly used 3 case definitions—the original Research definition, the CDC definition, and modifications of the Kansas definition—but they have not been compared against an objective standard. Methods All 3 case definitions...

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Bibliographic Details
Main Authors: Robert W. Haley, Jill A. Dever, Gerald Kramer, John F. Teiber
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Medical Research Methodology
Subjects:
Persian Gulf syndrome
Epidemiologic methods
Research design
Sensitivity and specificity
Statistical power
Environmental exposure
Online Access:https://doi.org/10.1186/s12874-023-02092-3

Internet

https://doi.org/10.1186/s12874-023-02092-3

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