TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks

TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks

TOPOVIBL and REC114 are required for meiotic DNA double-strand breaks (DSBs). This study shows that TOPOVIBL forms a complex with REC114 and mice carrying mutations that disrupt the interaction show DSB defects with distinct outcomes in males and females.

Bibliographic Details
Main Authors: Alexandre Nore, Ariadna B. Juarez-Martinez, Julie Clément, Christine Brun, Boubou Diagouraga, Hamida Laroussi, Corinne Grey, Henri Marc Bourbon, Jan Kadlec, Thomas Robert, Bernard de Massy
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34799-0

Internet

https://doi.org/10.1038/s41467-022-34799-0

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