Synthesis of 1-(2-Hydroxyphenyl)- and (3,5-Dichloro-2-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylic Acid Derivatives as Promising Scaffolds for the Development of Novel Antimicrobial and Anticancer Agents

Synthesis of 1-(2-Hydroxyphenyl)- and (3,5-Dichloro-2-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylic Acid Derivatives as Promising Scaffolds for the Development of Novel Antimicrobial and Anticancer Agents

Increasing antimicrobial resistance among Gram-positive pathogens and pathogenic fungi remains one of the major public healthcare threats. Therefore, novel antimicrobial candidates and scaffolds are critically needed to overcome resistance in Gram-positive pathogens and drug-resistant fungal pathoge...

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Bibliographic Details
Main Authors: Monika Bertašiūtė, Povilas Kavaliauskas, Rita Vaickelionienė, Birutė Grybaitė, Vidmantas Petraitis, Rūta Petraitienė, Ethan Naing, Andrew Garcia, Jūratė Šiugždaitė, Raimundas Lelešius, Vytautas Mickevičius
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
pyrrolidinone
hydrazone
azole
Gram-positive bacteria
antimicrobial activity
anticancer activity
Online Access:https://www.mdpi.com/1422-0067/24/9/7966

Internet

https://www.mdpi.com/1422-0067/24/9/7966

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