Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

Hedgehog-Interacting Protein (HHIP) is the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling. Here, the authors report structures of the HHIP N- and C-terminal domains, both in complexes with glycosaminoglycans, providing insights into the molecular basis for SHH sequestration and...

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Bibliographic Details
Main Authors: Samuel C. Griffiths, Rebekka A. Schwab, Kamel El Omari, Benjamin Bishop, Ellen J. Iverson, Tomas Malinauskas, Ramin Dubey, Mingxing Qian, Douglas F. Covey, Robert J. C. Gilbert, Rajat Rohatgi, Christian Siebold
Format: Article
Language:English
Published: Nature Portfolio 2021-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-27475-2

Internet

https://doi.org/10.1038/s41467-021-27475-2

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