Genetics and sex influence peripheral and central innate immune responses and blood-brain barrier integrity.

Genetics and sex influence peripheral and central innate immune responses and blood-brain barrier integrity.

Lipopolysaccharide (LPS) is a stimulator of the innate immune system and is routinely used in animal models to study blood-brain barrier (BBB) dysfunction under inflammatory conditions. It is appreciated that both humans and mice have sexually dimorphic immune responses, which could influence the br...

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Bibliographic Details
Main Authors: Michelle A Erickson, W Sandy Liang, Elizabeth G Fernandez, Kristin M Bullock, Jarl A Thysell, William A Banks
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6191122?pdf=render

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http://europepmc.org/articles/PMC6191122?pdf=render

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