Wenfei Buqi Tongluo Formula Against Bleomycin-Induced Pulmonary Fibrosis by Inhibiting TGF-β/Smad3 Pathway

Wenfei Buqi Tongluo Formula Against Bleomycin-Induced Pulmonary Fibrosis by Inhibiting TGF-β/Smad3 Pathway

Pulmonary fibrosis (PF) is the end stage of various chronic and progressive interstitial lung diseases. TGF-β, a profibrotic cytokine, can promote epithelial–mesenchymal transition (EMT), extracellular matrix (ECM) accumulation, and fibroblast proliferation, which contribute to progressive lung remo...

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Bibliographic Details
Main Authors: Lu Ding, Yaxin Li, Yingying Yang, Siyu Song, Hongyu Qi, Jing Wang, Ziyuan Wang, Jiachao Zhao, Wei Zhang, Linhua Zhao, Daqing Zhao, Xiangyan Li, Zeyu Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
WBT formula
network pharmacology
pulmonary fibrosis
extracellular matrix accumulation
epithelial–mesenchymal transition
TGF-β1/Smad3 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.762998/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.762998/full

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