Detection of Synaptic Proteins in Microglia by Flow Cytometry

Detection of Synaptic Proteins in Microglia by Flow Cytometry

A growing body of evidence indicates that microglia actively remove synapses in vivo, thereby playing a key role in synaptic refinement and modulation of brain connectivity. This phenomenon was mainly investigated in immunofluorescence staining and confocal microscopy. However, a quantification of s...

Full description

Bibliographic Details
Main Authors: Simone Brioschi, Paolo d’Errico, Lukas S. Amann, Hana Janova, Sonja M. Wojcik, Melanie Meyer-Luehmann, Lawrence Rajendran, Peter Wieghofer, Rosa C. Paolicelli, Knut Biber
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
microglia
synaptic pruning
VGLUT1
5xFAD model
TDP-43 conditional knock-out
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00149/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2020.00149/full

Similar Items