Cytomegalovirus downregulates IRE1 to repress the unfolded protein response.

Cytomegalovirus downregulates IRE1 to repress the unfolded protein response.

During viral infection, a massive demand for viral glycoproteins can overwhelm the capacity of the protein folding and quality control machinery, leading to an accumulation of unfolded proteins in the endoplasmic reticulum (ER). To restore ER homeostasis, cells initiate the unfolded protein response...

Full description

Bibliographic Details
Main Authors: Sebastian Stahl, Julia M Burkhart, Florian Hinte, Boaz Tirosh, Hermine Mohr, René P Zahedi, Albert Sickmann, Zsolt Ruzsics, Matthias Budt, Wolfram Brune
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3738497?pdf=render

Internet

http://europepmc.org/articles/PMC3738497?pdf=render

Similar Items