Age-related changes of protein SUMOylation balance in the AβPP Tg2576 mouse model of Alzheimer's disease

Age-related changes of protein SUMOylation balance in the AβPP Tg2576 mouse model of Alzheimer's disease

Alzheimer's disease (AD) is a complex disorder that affects the central nervous system causing a severe neurodegeneration. This pathology affects an increasing number of people worldwide due to the overall aging of the human population. In recent years SUMO protein modification has emerged as a...

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Bibliographic Details
Main Authors: Robert eNisticò, Caterina eFerraina, Veronica eMarconi, Fabio eBlandini, Lucia eNegri, Jan eEgebjerg, Marco eFeligioni
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer Disease
SUMO-1 Protein
Sumoylation
neurodegeneration
Tg2576
SENP1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00063/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00063/full

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