SARS-CoV-2 vaccination of convalescents boosts neutralization capacity against Omicron subvariants BA.1, BA.2 and BA.5 and can be predicted by anti-S antibody concentrations in serological assays

SARS-CoV-2 vaccination of convalescents boosts neutralization capacity against Omicron subvariants BA.1, BA.2 and BA.5 and can be predicted by anti-S antibody concentrations in serological assays

BackgroundRecent data on immune evasion of new SARS-CoV-2 variants raise concerns about the efficacy of antibody-based COVID-19 therapies. Therefore, in this study the in-vitro neutralization capacity against SARS-CoV-2 variant B.1 and the Omicron subvariants BA.1, BA.2 and BA.5 of sera from convale...

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Bibliographic Details
Main Authors: Alina Seidel, Simone Hoffmann, Bernd Jahrsdörfer, Sixten Körper, Carolin Ludwig, Christiane Vieweg, Dan Albers, Pascal von Maltitz, Rebecca Müller, Ramin Lotfi, Patrick Wuchter, Harald Klüter, Frank Kirchhoff, Michael Schmidt, Jan Münch, Hubert Schrezenmeier
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
vaccination
convalescent plasma
neutralization
omicron
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1170759/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1170759/full

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