A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) ’s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression.

A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) ’s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression.

Major depressive disorder (MDD) is primarily conceptualized as a mood disorder but cognitive dysfunction is also prevalent, and may limit the daily function of MDD patients. Current theories on MDD highlight disturbances in dendritic plasticity in its pathophysiology, which could conceivably play a...

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Bibliographic Details
Main Authors: Yan eLi, Alan L Pehrson, Jessica Ann Waller, Elena eDale, Connie eSanchez, Maria eGulinello
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Neuroscience
Subjects:
Cognition
neuroplasticity
Arc
Major Depressive Disorder
Arg3.1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00279/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00279/full

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