Interaction Tolerance Detection Test for Understanding the Killing Efficacy of Directional Antibiotic Combinations

ABSTRACT Combination treatments are commonly prescribed for enhancing drug efficacy, as well as for preventing the evolution of resistance. The interaction between drugs is typically evaluated near the MIC, using growth rate as a measure of treatment efficacy. However, for infections in which the ki...

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Bibliographic Details
Main Authors: Jia-Feng Liu, Orit Gefen, Zi-Yin Zhang, Min-Min Liu, Maskit Bar-Meir, Nathalie Q. Balaban
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mBio
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mbio.00004-22