An unexpected effect of TNF-α on F508del-CFTR maturation and function [v1; ref status: indexed, http://f1000r.es/5jf]

An unexpected effect of TNF-α on F508del-CFTR maturation and function [v1; ref status: indexed, http://f1000r.es/5jf]

Cystic fibrosis (CF) is a multifactorial disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which encodes a cAMP-dependent Cl- channel. The most frequent mutation, F508del, leads to the synthesis of a prematurely degraded, otherwise partially function...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän: Sara Bitam, Iwona Pranke, Monika Hollenhorst, Nathalie Servel, Christelle Moquereau, Danielle Tondelier, Aurélie Hatton, Valérie Urbach, Isabelle Sermet-Gaudelus, Alexandre Hinzpeter, Aleksander Edelman
Materialtyp: Artikel
Språk:English
Publicerad: F1000 Research Ltd 2015-07-01
Serie:F1000Research
Ämnen:
Cell Signaling
Control of Gene Expression
Genomics
Länkar:http://f1000research.com/articles/4-218/v1

Internet

http://f1000research.com/articles/4-218/v1

Liknande verk