ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice

ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice

Cannabidiol (CBD) is currently being investigated as a novel therapeutic for the treatment of CNS disorders like schizophrenia and epilepsy. ABC transporters such as P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp) mediate pharmacoresistance in these disorders. P-gp and Bcrp are exp...

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Bibliographic Details
Main Authors: Natalia Brzozowska, Kong M. Li, Xiao Suo Wang, Jessica Booth, Jordyn Stuart, Iain S. McGregor, Jonathon C. Arnold
Format: Article
Language:English
Published: PeerJ Inc. 2016-05-01
Series:PeerJ
Subjects:
Cannabidiol
P-glycoprotein
Breast cancer resistance protein
Substrate
Brain disposition
ABC transporters
Online Access:https://peerj.com/articles/2081.pdf

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https://peerj.com/articles/2081.pdf

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