Multiomics profiling of urothelial carcinoma in situ reveals CIS-specific gene signature and immune characteristics

Multiomics profiling of urothelial carcinoma in situ reveals CIS-specific gene signature and immune characteristics

Summary: Urothelial carcinoma in situ (CIS) is an aggressive phenotype of non-muscle-invasive bladder cancer. Molecular features unique to CIS compared to high-grade papillary tumors are underexplored. RNA sequencing of CIS, papillary tumors, and normal urothelium showed lower immune marker expressi...

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Bibliographic Details
Main Authors: Meenakshi Anurag, Trine Strandgaard, Sung Han Kim, Yongchao Dou, Eva Comperat, Hikmat Al-Ahmadie, Brant A. Inman, Ann Taber, Iver Nordentoft, Jørgen Bjerggaard Jensen, Lars Dyrskjøt, Seth P. Lerner
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:iScience
Subjects:
Immunology
Cancer
Omics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224004000

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http://www.sciencedirect.com/science/article/pii/S2589004224004000

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