Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model.

Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model.

beta-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known if beta-amyloid contributes to intellectual disability in younger individuals. We used a gamma-secreta...

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Bibliographic Details
Main Authors: William J Netzer, Craig Powell, Yi Nong, Jacqueline Blundell, Lili Wong, Karen Duff, Marc Flajolet, Paul Greengard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2880593?pdf=render

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http://europepmc.org/articles/PMC2880593?pdf=render

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