Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State

Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State

Induced pluripotent stem cells (iPSCs) hold great promise for personalized regenerative medicine. However, recent studies show that iPSC lines carry genetic abnormalities, suggesting that reprogramming may be mutagenic. Here, we show that the ectopic expression of reprogramming factors increases the...

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Bibliographic Details
Main Authors: Federico González, Daniela Georgieva, Fabio Vanoli, Zhong-Dong Shi, Matthias Stadtfeld, Thomas Ludwig, Maria Jasin, Danwei Huangfu
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713000648

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http://www.sciencedirect.com/science/article/pii/S2211124713000648

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