Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling

Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling

Summary: CSF-1R haploinsufficiency causes adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). Previous studies in the Csf1r+/− mouse model of ALSP hypothesized a central role of elevated cerebral Csf2 expression. Here, we show that monoallelic deletion of Csf2 rescues mo...

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Main Authors: Violeta Chitu, Fabrizio Biundo, Gabriel G.L. Shlager, Eun S. Park, Ping Wang, Maria E. Gulinello, Şölen Gokhan, Harmony C. Ketchum, Kusumika Saha, Michael A. DeTure, Dennis W. Dickson, Zbignew K. Wszolek, Deyou Zheng, Andrew L. Croxford, Burkhard Becher, Daqian Sun, Mark F. Mehler, E. Richard Stanley
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720301893

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http://www.sciencedirect.com/science/article/pii/S2211124720301893

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