Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

The selenoenzyme glutathione peroxidase 4 (Gpx4) is an essential mammalian glutathione peroxidase, which protects cells against detrimental lipid peroxidation and governs a novel form of regulated necrotic cell death, called ferroptosis. To study the relevance of Gpx4 and of another vitally importan...

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Bibliographic Details
Main Authors: Bradley A. Carlson, Ryuta Tobe, Elena Yefremova, Petra A. Tsuji, Victoria J. Hoffmann, Ulrich Schweizer, Vadim N. Gladyshev, Dolph L. Hatfield, Marcus Conrad
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Redox Biology
Subjects:
Selenoprotein
Ferroptosis
Lipid peroxidation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716300350

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http://www.sciencedirect.com/science/article/pii/S2213231716300350

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