Structural insights into catalytical capability for CPT11 hydrolysis and substrate specificity of a novel marine microbial carboxylesterase, E93

Structural insights into catalytical capability for CPT11 hydrolysis and substrate specificity of a novel marine microbial carboxylesterase, E93

IntroductionCPT11 (Irinotecan; 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin) is an important camptothecin-based broad-spectrum anticancer prodrug. The activation of its warhead, SN38 (7-ethyl-10-hydroxycamptothecin), requires hydrolysis by carboxylesterases. NPC (7-ethyl-10-[4-...

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Bibliographic Details
Main Authors: Yang Li, Zhen Rong, Zhengyang Li, Henglin Cui, Jixi Li, Xue-Wei Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Microbiology
Subjects:
marine bacterial carboxylesterase
crystal structure
enzyme catalysis
prodrug
p-nitrophenyl
substrate specificity
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1081094/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.1081094/full

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