m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis

m6A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis

Ime4p is a yeast N6-methyladenosine (m6A) methyltransferase with an unknown role in meiosis. Rme1p is a repressor of meiosis. Here the authors show that Ime4p methylates RME1 3′ UTR to reduce its expression and enable meiosis, thus providing an example of an m6A site with a physiological role.

Bibliographic Details
Main Authors: G. Guy Bushkin, David Pincus, Jeffrey T. Morgan, Kris Richardson, Caroline Lewis, Sze Ham Chan, David P. Bartel, Gerald R. Fink
Format: Article
Language:English
Published: Nature Portfolio 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11232-7

Internet

https://doi.org/10.1038/s41467-019-11232-7

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