Conserved Double Translation Initiation Site for Δ160p53 Protein Hints at Isoform’s Key Role in Mammalian Physiology

Conserved Double Translation Initiation Site for Δ160p53 Protein Hints at Isoform’s Key Role in Mammalian Physiology

<i>p53</i> is the most commonly mutated gene in human cancers. Two fundamental reasons for this are its long protein isoforms protect from cancer, while its shorter C-terminal isoforms can support cancer and metastasis. Previously, we have shown that the Δ160p53 protein isoform enhances...

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Bibliographic Details
Main Authors: Maria José López-Iniesta, Shrutee N. Parkar, Ana Catarina Ramalho, Rafaela Lacerda, Inês F. Costa, Jingyuan Zhao, Luísa Romão, Marco M. Candeias
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
Δ160p53
p53
translation
cancer
p53 isoform
p53 mRNA
Online Access:https://www.mdpi.com/1422-0067/23/24/15844

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