Wavelet coherence phase analysis decodes the universal switching mechanism of Ras GTPase superfamily

Summary: The Ras superfamily of GTPases regulate critical cellular processes by shuttling between GTP-bound ON and GDP-bound OFF states. This switching mechanism is attributed to the conformational changes in two loops, SWI and SWII, upon GTP binding and hydrolysis. Since these conformational change...

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Bibliographic Details
Main Authors: Zenia Motiwala, Anand S. Sandholu, Durba Sengupta, Kiran Kulkarni
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223011082