Prevalence of five pharmacologically most important CYP2C9 and CYP2C19 allelic variants in the population from the Republic of Srpska in Bosnia and Herzegovina

Prevalence of five pharmacologically most important CYP2C9 and CYP2C19 allelic variants in the population from the Republic of Srpska in Bosnia and Herzegovina

The enzymes of the cytochrome P450 superfamily play a critical role in phase I drug metabolism. Among them, CYP2C9 and CYP2C19 are clinically important, as they can mediate severe toxicity, therapy failure, and increased susceptibility to cancer and other diseases caused by chemicals. The aim of thi...

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Bibliographic Details
Main Authors: Vidović Stojko, Škrbić Ranko, Stojiljković Miloš P., Vidović Vanja, Bećarević Jelena, Stoisavljević-Šatara Svjetlana, Maksimović Nela
Format: Article
Language:English
Published: Sciendo 2021-06-01
Series:Arhiv za Higijenu Rada i Toksikologiju
Subjects:
cytochrome p450 enzymes
pharmacogenetics
polymorphic allele
enzimi citokroma 450
farmakogenetika
polimorfizam alela
Online Access:https://doi.org/10.2478/aiht-2021-72-3499

Internet

https://doi.org/10.2478/aiht-2021-72-3499

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