Renal NKCC2 Is Dual Regulated by the Synergy of 20-HETE and High-Fat Diet in CYP4F2 Transgenic Mice

Introduction: 20-Hydroxyeicosatetraenoic acid (20-HETE) is the metabolite of cytochrome P450, which modulates blood pressure by inhibiting renal sodium transport. However, the molecular mechanisms underlying the role of 20-HETE in the development of obesity-related hypertension remain unclear, neces...

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Bibliographic Details
Main Authors: Jingjing Wu, Guangrui Lai, Fangjie Chen, Bijun Zhang, Yanyan Zhao
Format: Article
Language:English
Published: Karger Publishers 2021-07-01
Series:Kidney & Blood Pressure Research
Subjects:
Online Access:https://www.karger.com/Article/FullText/517382