Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation

Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation

Summary: Seven in absentia homolog 1 (SIAH1) was reported to be downregulated in hepatocellular carcinoma (HCC) and played an important role in HCC progression; however, the underlying reason remains unknown. Here, we found that Cathepsin K (CTSK), a protein potentially interacting with SIAH1, inhib...

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Bibliographic Details
Main Authors: Chengming Zhang, Zhiyi Liu, Xiaotian Wang, Bin Zhang, Licheng Cui, Qinghe Hu, Bin Hu, Kuan Cao, Wengang Shan, Hengliang Shi, Renhao Wang
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Molecular biology
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422300929X

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http://www.sciencedirect.com/science/article/pii/S258900422300929X

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