Overexpression of Adenylyl Cyclase Encoded by the Mycobacterium tuberculosis Rv2212 Gene Confers Improved Fitness, Accelerated Recovery from Dormancy and Enhanced Virulence in Mice

Overexpression of Adenylyl Cyclase Encoded by the Mycobacterium tuberculosis Rv2212 Gene Confers Improved Fitness, Accelerated Recovery from Dormancy and Enhanced Virulence in Mice

Earlier we demonstrated that the adenylyl cyclase (AC) encoded by the MSMEG_4279 gene plays a key role in the resuscitation and growth of dormant Mycobacterium smegmatis and that overexpression of this gene leads to an increase in intracellular cAMP concentration and prevents the transition of M. sm...

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Bibliographic Details
Main Authors: Margarita O. Shleeva, Tatyana K. Kondratieva, Galina R. Demina, Elvira I. Rubakova, Anna V. Goncharenko, Alexander S. Apt, Arseny S. Kaprelyants
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Mycobacterium tuberculosis
cAMP
adenylyl cyclase
Rv2212
dormant mycobacteria
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00370/full

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http://journal.frontiersin.org/article/10.3389/fcimb.2017.00370/full

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