Chromosomal Instability Causes Sensitivity to Polyamines and One-Carbon Metabolism

Chromosomal Instability Causes Sensitivity to Polyamines and One-Carbon Metabolism

Aneuploidy, or having a disrupted genome, is an aberration commonly found in tumours but rare in normal tissues. It gives rise to proteotoxic stress as well as a stereotypical oxidative shift, which makes these cells sensitive to internal and environmental stresses. Using <i>Drosophila</i&g...

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Bibliographic Details
Main Authors: Anowarul Islam, Zeeshan Shaukat, David L. Newman, Rashid Hussain, Michael G. Ricos, Leanne Dibbens, Stephen L. Gregory
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Metabolites
Subjects:
s-adenosyl methionine
spermine
genomic instability
reactive oxygen species (ROS)
<i>Drosophila</i>
autophagy
Online Access:https://www.mdpi.com/2218-1989/13/5/642

Internet

https://www.mdpi.com/2218-1989/13/5/642

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