Human coculture model of astrocytes and SH-SY5Y cells to test the neurotoxicity of chemicals

Human coculture model of astrocytes and SH-SY5Y cells to test the neurotoxicity of chemicals

In this study, we established a coculture model comprising human neuroblastoma SH-SY5Y cells and induced pluripotent stem cell-derived astrocytes, faithfully replicating the human brain environment for in vitro neurotoxicity assessment. We optimized the cell differentiation duration and cell ratios...

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Bibliographic Details
Main Authors: Seungmin Park, Ha-Na Oh, Woo-Keun Kim
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Coculture
Neurotoxicity
SH-SY5Y
Astrocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323014161

Internet

http://www.sciencedirect.com/science/article/pii/S0147651323014161

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