Adipose METTL14‐Elicited N6‐Methyladenosine Promotes Obesity, Insulin Resistance, and NAFLD Through Suppressing β Adrenergic Signaling and Lipolysis

Adipose METTL14‐Elicited N6‐Methyladenosine Promotes Obesity, Insulin Resistance, and NAFLD Through Suppressing β Adrenergic Signaling and Lipolysis

Abstract White adipose tissue (WAT) lipolysis releases free fatty acids as a key energy substance to support metabolism in fasting, cold exposure, and exercise. Atgl, in concert with Cgi‐58, catalyzes the first lipolytic reaction. The sympathetic nervous system (SNS) stimulates lipolysis via neurotr...

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Bibliographic Details
Main Authors: Qianqian Kang, Xiaorong Zhu, Decheng Ren, Alexander Ky, Ormond A. MacDougald, Robert W. O'Rourke, Liangyou Rui
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Advanced Science
Subjects:
β‐adrenergic signaling
adipose tissue
diabetes
lipolysis
m6A
obesity
Online Access:https://doi.org/10.1002/advs.202301645

Internet

https://doi.org/10.1002/advs.202301645

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