Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm silver nanoparticle aerosols in healthy adult rats after a single 1½-hour inhalation exposure

Quantitative biokinetics over a 28 day period of freshly generated, pristine, 20 nm silver nanoparticle aerosols in healthy adult rats after a single 1½-hour inhalation exposure

Abstract Background There is a steadily increasing quantity of silver nanoparticles (AgNP) produced for numerous industrial, medicinal and private purposes, leading to an increased risk of inhalation exposure for both professionals and consumers. Particle inhalation can result in inflammatory and al...

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Bibliographic Details
Main Authors: Wolfgang G. Kreyling, Uwe Holzwarth, Stephanie Hirn, Carsten Schleh, Alexander Wenk, Martin Schäffler, Nadine Haberl, Neil Gibson
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Particle and Fibre Toxicology
Subjects:
Spark ignition generated silver nanoparticle (NP) aerosols
Characterization of physicochemical NP properties
Intratracheal inhalation of freshly generated aerosols
Ionic silver released from the NP surface precipitate as low-solubility silver-salt precipitates in body fluids
Prolonged dissolution in body fluids due to low-solubility silver-salt layers on the surface of NP cores
Competing translocation of silver NP cores versus low-solubility silver-salt precipitates across the air-blood-barrier
Online Access:http://link.springer.com/article/10.1186/s12989-020-00347-1

Internet

http://link.springer.com/article/10.1186/s12989-020-00347-1

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