Factors Influencing the Differentiation of Human Monocytic Myeloid-Derived Suppressor Cells Into Inflammatory Macrophages

Factors Influencing the Differentiation of Human Monocytic Myeloid-Derived Suppressor Cells Into Inflammatory Macrophages

Monocytic myeloid-derived suppressor cells (mMDSC) accumulate within tumors where they create an immunosuppressive milieu that inhibits the activity of cytotoxic T and NK cells thereby allowing cancers to evade immune elimination. The toll-like receptors 7/8 agonist R848 induces human mMDSC to matur...

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Bibliographic Details
Main Authors: Defne Bayik, Debra Tross, Dennis M. Klinman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
myeloid-derived suppressor cells
inflammatory macrophage
TNFα
STAT4
NF-κB
IFNγ
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00608/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00608/full

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