Synthesis and Effects of 4,5-Diaryl-2-(2-alkylthio-5-imidazolyl) Imidazoles as Selective Cyclooxygenase Inhibitors

Synthesis and Effects of 4,5-Diaryl-2-(2-alkylthio-5-imidazolyl) Imidazoles as Selective Cyclooxygenase Inhibitors

Objective(s)In recent years highly selective COX-2inhibitors were withdrawn from the market because of an increased risk of cardiovascular complications. In this study we were looking for potent compounds with moderate selectivity for cox-2. So, four analogues of 4, 5-diaryl-2-(2-alkylthio-5-imidazo...

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Bibliographic Details
Main Authors: Mohammad Reza Saberi, Farzin Hadizadeh, Mohsen Imenshahidi, Hadi Shakeri, Seyedeh Toktam Ziaee, Mohammad Ali Ghafuri, Ramin Sakhtianchi, Zohreh Badieyan, Somieh Hajian
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2010-09-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Analgesic
Anti-inflammatory
Imidazoles
Online Access:http://www.mums.ac.ir/shares/basic_medical/basicmedjou/89/fall/a10.pdf

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